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Posts Tagged ‘cancer’

The coming cancer crunch

By Dr. Peter Craighead
For The Calgary Herald — March 18, 2010

Publicly funded health care is only sustainable by focusing on and providing what is needed by its constituents.

During the boom years, many Albertans and their health-care leaders assumed we could ask for whatever we wanted. The truth is that Alberta’s health-care system now is forced to balance the needs of our public against the wants of its health-care leaders, whether this is in the provision of surgical services for joint replacement, caring for stroke patients or funding expensive cancer treatment.

The Rolling Stones aptly describe this in their song: “You can’t always get what you want, but if you try sometime you just might find, you get what you need.” The recent flurry of discussions around a new cancer centre in Calgary forces us to ask whether this is a need or a want.

Almost one in two Albertans will develop cancer in their lifetime, and one in four will die from this disease. Another way of looking at this is to realize that there were 14,500 new cancer cases diagnosed in 2009, and there are an estimated 80,000 people living with cancer in our province. About 85 per cent of these cancer patients will be seen and treated at cancer centres around the province. The Tom Baker Cancer Centre in Calgary is one of two major centres in the province, currently sees 150,000 patient visits annually and is the major referral centre for cancer care in southern Alberta.

So what is it that Albertans need when it comes to cancer care, and how has the system responded to this? Albertans with cancer need to receive state-of-the-art treatments in a timely, respectful manner; they should have access to care as close to home as possible; and they should not suffer pain or emotional distress. We also believe that Albertans should have access to prevention strategies that reduce the incidence of cancer and screening that finds the disease at an early, curable stage.

Until the second half of the last decade, Alberta’s health system responded well to these needs. For example, by the early 2000s the province had built up a network of facilities across the province, was highly responsive to cancer drug treatment requests and supported the purchase of expensive radiotherapy equipment in Edmonton and Calgary. Alberta was considered one of the best places to receive cancer treatment, and the place to work if you were a cancer specialist. This was evidenced by the successful recruitment of medical specialists, researchers, nurses and other professionals.

The rapid growth of Alberta’s population, continued increase in cancer numbers, success in recruitment and the change in our health system have all contributed to a growing capacity problem for us. Facilities in Edmonton and Calgary have outstripped their space, leading to a significant impact on patient experience. Cancer care has worked with the province to identify solutions, including the distribution of radiotherapy to smaller cities, plans to expand buildings in Edmonton and Calgary, and using leased space to tide us over for the medium term. We are also improving efficiencies within our centres to increase patient throughput.

The TBCC responded by moving some functions off site, because there was no available expansion space at Foothills Hospital. Since 2003, we have completed two phases of renovations in leased space at the Holy Cross Hospital, and the space we are currently renovating will allow us to expand treatment facilities at the Tom Baker site, so we can sustain our comprehensive service to cancer patients for southern Alberta for at least another three years. A few years ago, we also relocated many of the day procedures that we previously performed within the TBCC to the Foothills, but it is apparent that the rest of the system has minimal capacity to accommodate any further growth. Finally, we are in discussion with South Health Campus planners to see whether that space will provide us options for dealing with our space crunch in the medium term.

How have these decisions affected patient experience in Calgary? As I write this, patients experience serious overcrowding in our facilities, are made to travel between sites for various parts of their clinical care and some of them have excessive wait times to get in to see oncologists.

Fortunately, the wait times for treatment other than surgery continue to fall within our guidelines of two weeks for chemotherapy and eight weeks for radiotherapy. But the fragmentation of services into two sites means patients cannot take advantage of all services at one time. A further complication of providing clinical services across the city is that our clinical staff becomes less efficient by having to include transit times into their day. Simply put, distributing the services of one cancer centre within a city provides a suboptimal patient experience compared with full-service cancer centres.

Predictions tell us that by 2013, when the breathing room provided by Holy Cross will have been exhausted, we can expect to be seeing six to eight per cent more new cases, and to be treating 10 per cent more patients. Although the opening of Lethbridge radiotherapy facilities will help us deal especially with radiotherapy referrals, and the increase in throughput initiatives will gain some efficiencies in chemotherapy treatments, it is predicted that we will be facing severe shortages in Calgary by 2013. Given the budgetary pressures facing Alberta Health Services, it will take significant focus on our part to see a co-ordinated strategy for cancer in the next 12 months. The short-and medium-term solutions we have employed have allowed us to provide excellent care, albeit of a somewhat fragmented nature.

AHS has made efforts to respond to cancer patients’ needs in the short term, but we now must challenge ourselves to move away from a “building the new system” mode into focusing on how to address the longer-term needs of patients, including the particular needs of cancer patients in Calgary.

As a medical leader within AHS Cancer Care, I am ready to support any planning process that ensures that future patients in Calgary are provided a superior experience, and that we are able to address their need to receive timely, quality care.

Peter Craighead, MD FRCPC, is senior radiation oncologist and director of the Tom Baker Cancer Centre.

Read more: http://www.calgaryherald.com/health/coming+cancer+crunch/2695990/story.html#ixzz0iXuD3sPl

New study says Alzheimer’s drug may be key to stop spread of aggressive brain cancers

December 4, 2008 1 comment

By Kyle Glennie
Posted December 4, 2008

Photo by Chris Kindratsky

Photo by Chris Kindratsky

Researchers working jointly for the University of Calgary and Alberta Health Services have discovered a way to help stop aggressive brain tumours from spreading by using an existing drug that is being tested for Alzheimer’s patients.  The findings are published in the scientific journal Public Library of Science Biology.

Dr. Peter Forsyth, and Donna Senger, PhD, along with their colleagues identified a “switch” that enables brain cancer cells to journey outwards from the primary tumour. They first discovered the switch in August 2007, which is a mechanism that allows brain tumours to invade and spread within the brain.   Their research focused on malignant gliomas-highly invasive tumours that are extremely resistant to conventional treatments such as radiation and chemotherapy.

Forsyth and Senger found the switch is activated by a protein that is already present in the brain.  Now, with the laboratories of Stephen Robbins, PhD, a member of the Alberta Cancer Research Institute and Samuel Weiss, PhD, the Director of the Hotchkiss Brain Institute at the Faculty of Medicine, they’ve found a way to stop this protein from activating the switch.

“We’ve basically found this switch is turned on when it is cut by “a pair of scissors” found in our brains.  What’s exciting is that we’ve discovered there is a family of drugs that block these scissors from cutting the protein and it’s already being tested in Alzheimer’s patients,” says Forsyth.  “We’ve also found this process is present in cancer stem cells which many believe accounts for failures of our treatments in many patients.”

With these drugs already in clinical testing, Forsyth and Senger are optimistic they will be able to further their effectiveness on malignant gliomas in their own clinical trials much faster.

“A lot of background work has been done with these drugs already in terms of understanding their dose and side effects, so we’re hopeful that we can move this rapidly into the clinic,” says Forsyth.

Partnerships made it possible

Ken Hughes, chair of the Alberta Health Services Board, says the research demonstrates the value of partnership between universities and health care. “It’s exciting to see these researchers planning to take discoveries like this to clinical trial here in Alberta, where Alberta patients  can be the first to benefit.”

“One of my ministry’s priorities is bringing technology to market, and technology often starts with research” said Doug Horner, Minister of Advanced Education and Technology. “In the coming years, Albertans will hear more about our province’s leadership in research and innovation, including research to create new drugs to treat cancer, new devices to diagnose it and, as in this case, new ways to repurpose today’s medical advances for tomorrow’s patients.”

The next step for the researchers is two-fold: to find a specific drug within the drug family to test in a clinical setting, and to make the drug as effective and as safe as possible.  They also have another funding grant in place that allows them to try and redesign these drugs to better suit their purpose, something they are also investigating.

Patient says the treatment gives new hope

Rob Evans was not part of the study but as someone who was diagnosed with a cancerous brain tumour 15 years ago he says the research provides patients with new hope and the potential of less invasive treatment. Evans’ treatment regiment included surgery, radiation and chemotherapy.  “Any time you can do reduce the stress for someone dealing with cancer and provide a better chance of survival you’ve hit a home run.”

While the team’s research focused on brain tumours, the findings could also have an impact on the treatment of other types of cancers.  Skin cancer is also spread through the activation of a switch by this type of protein, and Forsyth would like to try this new approach on melanoma.

“It’s an interesting idea that you can use a drug to block the invasion of cancer cells into normal human tissue, but to have that drug already being used in clinical trials is a dream come true,” he said.

Dr. Peter Forsyth is a professor in the departments of Oncology, Clinical Neurosciences, and Biochemistry & Molecular Biology at the Faculty of Medicine. He is also the southern Director of ACRI (the Alberta Cancer Research Institute), the Associate Director of Research at the Tom Baker Cancer Centre, and is a former director of the Clark H. Smith Brain Tumor Centre.

Donna Senger, PhD, is a research assistant professor in the department of Oncology at the Faculty of Medicine, and has been a part of Dr. Forsyth’s research group since 2000.  Senger has contributed regularly to numerous studies and publications that are directly focused on increasing our understanding of brain tumour progression and therapeutic intervention.

Stephen Robbins, PhD is an associate professor in the departments of Oncology and Biochemistry and Molecular Biology at the Faculty of Medicine.  He is a scientist of the Alberta Heritage Foundation for Medical Research (AHFMR) and currently holds a Canada Research Chair in the Cancer Biology.

Samuel Weiss, PhD, is a professor in the department of Cell Biology and Anatomy at the Faculty of Medicine.  He is the Director of the Hotchkiss Brain Institute and is a scientist of the AHFMR.  Weiss was a recent recipient of the very prestigious Gairdner Award for his discovery of neural stem cells.

Their work is supported in part by a generous donation from the Clark H. Smith family, the Canadian Institutes of Health Research (CIHR), Alberta Health Services–(Alberta Cancer Board) and the Alberta Cancer Foundation.

A copy of the study can be downloaded at:

http://biology.plosjournals.org/archive/1545-7885/6/11/pdf/10.1371_journal.pbio.0060289-L.pdf